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cnqx  (Alomone Labs)


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    Structured Review

    Alomone Labs cnqx
    Cnqx, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 95/100, based on 39 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/cnqx/CNQX/bio_rxiv__64898__2026__05__01__719272-186-8-9
    Average 95 stars, based on 39 article reviews
    cnqx - by Bioz Stars, 2026-09
    95/100 stars

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    Related Articles

    Sterility:

    Article Title: Nanoscale CaV channel reorganization links α-synuclein pathology to calcium-dependent transcriptional dysregulation
    Article Snippet: TAT-HA-C1aB (CCAD) and the corresponding scrambled control peptide TAT-HA-C1aB-Scr (SCRBL) (peptide sequences provided in Supplementary table 1) were dissolved in sterile molecular biology-grade water and applied at a final concentration of 1 μM for 24 h. Roscovitine (Sigma, R7772) was dissolved in DMSO and applied at a final concentration of 10 μM for 24 h, control experiments included an equivalent volume of DMSO. .. Tetrodotoxin (TTX; Alomone, T-550), D-AP5 (Alomone, D-145), and CNQX (Alomone, C-141) were dissolved in sterile molecular biology-grade water and applied for 2 h at final concentrations of 1 μM, 10 μM, and 50 μM, respectively. .. Nimodipine (Alomone, N-150) was dissolved in DMSO and applied at a final concentration of 10 μM for 90 s.

    other:

    Article Title: VTA GABA Cell Bipotential Induction of iLTP or iLTD Synaptic Plasticity is Input Selective, where iLTD is Uniquely Eliminated by Cocaine
    Article Snippet: CNQX (Alomone Labs), picrotoxin (Tocris) and cocaine (NIDA) were dissolved in ddH2O to make stock solutions.

    Transmission Assay:

    Article Title: Electrophysiologically calibrated optogenetic stimulation of dentate granule cells mitigates dendritic spine loss in denervated organotypic entorhino-hippocampal slice cultures
    Article Snippet: Cultures were transferred to a custom-made, temperature-controlled recording chamber mounted on the stage of a confocal laser scanning microscope (Fluoview 3000 on a BX63L upright microscope stand, equipped with a 60x NA 1.0 water immersion objective lens, Olympus/Evident) where they were superfused with artificial cerebrospinal fluid (ACSF) containing 126 mM NaCl, 2.5 mM KCl, 1.25 mM NaH 2 PO 4 , 2 mM MgCl 2 , 2 mM CaCl 2 , 26 mM NaHCO 3 and 10 mM glucose, oxygenated with carbogen (95% O 2 / 5% CO 2 ) at 35 °C. .. Excitatory and inhibitory synaptic transmission was blocked by 10 μM CNQX (6-cyano-7-nitroquinoxaline-2,3-dione, Alomone labs), 10 μM D-AP5 (D-2-amino-5-phosphonopentanoic acid, Alomone labs) and 10 μM gabazine (SR95531 hydrobromide, Alomone labs). .. 3–7 MΩ patch-pipettes were pulled from borosilicate glass capillaries (Harvard Apparatus GC150TF-10) with a DMZ universal puller (Zeitz) and filled with K-gluconate-based internal solution: 126 mM K-gluconate, 4 mM KCl, 10 mM HEPES, 2 mM MgATP, 0.2 mM NaGTP, 10 mM phosphocreatine, and 0.3% (w/v) biocytin, pH 7.25, osmolarity adjusted to 290–300 mOsm/kg with sucrose.

    Article Title: Electrophysiologically calibrated optogenetic stimulation of dentate granule cells mitigates dendritic spine loss in denervated organotypic entorhino-hippocampal slice cultures.
    Article Snippet: Cultures were transferred to a custom-made, temperature-controlled recording chamber mounted on the stage of a confocal laser scanning microscope (Fluoview 3000 on a BX63L upright microscope stand, equipped with a 60x NA 1.0 water immersion objective lens, Olympus/Evident) where they were superfused with artificial cerebrospinal fluid (ACSF) containing 126 mM NaCl, 2.5 mM KCl, 1.25 mM NaH2PO4, 2 mM MgCl2, 2 mM CaCl2, 26 mM NaHCO3 and 10 mM glucose, oxygenated with carbogen (95% O2/ 5% CO2) at 35 °C. .. Excitatory and inhibitory synaptic transmission was blocked by 10 μM CNQX (6-cyano-7-nitroquinoxaline-2,3-dione, Alomone labs), 10 μM D-AP5 (D-2-amino-5-phosphonopentanoic acid, Alomone labs) and 10 μM gabazine (SR95531 hydrobromide, Alomone labs). .. 3–7 MΩ patch-pipettes were pulled from borosilicate glass capillaries (Harvard Apparatus GC150TF-10) with a DMZ universal puller (Zeitz) and filled with K-gluconate-based internal solution: 126 mM K-gluconate, 4 mM KCl, 10 mM HEPES, 2 mM MgATP, 0.2 mM NaGTP, 10 mM phosphocreatine, and 0.3% (w/v) biocytin, pH 7.25, osmolarity adjusted to 290–300 mOsm/kg with sucrose.

    Saline:

    Article Title: Repeated administration of AMPA/kainate antagonists transiently suppresses nicotine-seeking in an operant rat model.
    Article Snippet: .. CNQX was purchased from Alomone Labs Ltd. (Jerusalem, Israel) and dissolved in saline to obtain a 6 mg/ml concentration. ..

    Concentration Assay:

    Article Title: Repeated administration of AMPA/kainate antagonists transiently suppresses nicotine-seeking in an operant rat model.
    Article Snippet: .. CNQX was purchased from Alomone Labs Ltd. (Jerusalem, Israel) and dissolved in saline to obtain a 6 mg/ml concentration. ..



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    cnqx  (Tocris)
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    Effects of serotonin and 5-HT receptor compounds on ARN KISS neuron firing in acute brain slices from diestrous female mice. (A) Robust excitatory effect of 90 seconds puff of 40 µM serotonin on firing rate of a middle ARN kisspeptin neuron. (B) Inhibitory effect of 90 seconds puff of 60 µM serotonin on firing rate of a caudal ARN kisspeptin neuron initially stimulated to fire by a 200 nM puff of NKB. (C) Rostral ARN kisspeptin neuron not responding to 60 µM puffs of serotonin but later activated by NKB. (D) Summary of percentage of rostral (rARN), middle (mARN), and caudal (cARN) kisspeptin neurons excited or inhibited by serotonin. (E) Caudal ARN kisspeptin neuron activated by serotonin (40 µM) in the absence and presence of methiothepin (100 µM). (F) Middle ARN kisspeptin neuron in which the excitatory effect of serotonin (40 µM) is blocked by methiothepin (100 µM). (G) Middle ARN kisspeptin neuron activated by serotonin (40 µM) in the absence and presence of SB228357 (100 µM). (H) Caudal ARN kisspeptin neuron in which zacopride (2 µM) facilitates serotonin excitation. (I) Whole-cell recording from an ARN KISS neuron in the continuous presence of TTX, <t>CNQX,</t> <t>DAP5,</t> and bicuculline, showing depolarization during bath application of 5-HT (30 µM). (J) Summary of mean membrane potential measured predrug, during 5-HT application, and following wash ( P < .001; n = 4 animals).
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    Effects of serotonin and 5-HT receptor compounds on ARN KISS neuron firing in acute brain slices from diestrous female mice. (A) Robust excitatory effect of 90 seconds puff of 40 µM serotonin on firing rate of a middle ARN kisspeptin neuron. (B) Inhibitory effect of 90 seconds puff of 60 µM serotonin on firing rate of a caudal ARN kisspeptin neuron initially stimulated to fire by a 200 nM puff of NKB. (C) Rostral ARN kisspeptin neuron not responding to 60 µM puffs of serotonin but later activated by NKB. (D) Summary of percentage of rostral (rARN), middle (mARN), and caudal (cARN) kisspeptin neurons excited or inhibited by serotonin. (E) Caudal ARN kisspeptin neuron activated by serotonin (40 µM) in the absence and presence of methiothepin (100 µM). (F) Middle ARN kisspeptin neuron in which the excitatory effect of serotonin (40 µM) is blocked by methiothepin (100 µM). (G) Middle ARN kisspeptin neuron activated by serotonin (40 µM) in the absence and presence of SB228357 (100 µM). (H) Caudal ARN kisspeptin neuron in which zacopride (2 µM) facilitates serotonin excitation. (I) Whole-cell recording from an ARN KISS neuron in the continuous presence of TTX, <t>CNQX,</t> <t>DAP5,</t> and bicuculline, showing depolarization during bath application of 5-HT (30 µM). (J) Summary of mean membrane potential measured predrug, during 5-HT application, and following wash ( P < .001; n = 4 animals).
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    Image Search Results


    Effects of serotonin and 5-HT receptor compounds on ARN KISS neuron firing in acute brain slices from diestrous female mice. (A) Robust excitatory effect of 90 seconds puff of 40 µM serotonin on firing rate of a middle ARN kisspeptin neuron. (B) Inhibitory effect of 90 seconds puff of 60 µM serotonin on firing rate of a caudal ARN kisspeptin neuron initially stimulated to fire by a 200 nM puff of NKB. (C) Rostral ARN kisspeptin neuron not responding to 60 µM puffs of serotonin but later activated by NKB. (D) Summary of percentage of rostral (rARN), middle (mARN), and caudal (cARN) kisspeptin neurons excited or inhibited by serotonin. (E) Caudal ARN kisspeptin neuron activated by serotonin (40 µM) in the absence and presence of methiothepin (100 µM). (F) Middle ARN kisspeptin neuron in which the excitatory effect of serotonin (40 µM) is blocked by methiothepin (100 µM). (G) Middle ARN kisspeptin neuron activated by serotonin (40 µM) in the absence and presence of SB228357 (100 µM). (H) Caudal ARN kisspeptin neuron in which zacopride (2 µM) facilitates serotonin excitation. (I) Whole-cell recording from an ARN KISS neuron in the continuous presence of TTX, CNQX, DAP5, and bicuculline, showing depolarization during bath application of 5-HT (30 µM). (J) Summary of mean membrane potential measured predrug, during 5-HT application, and following wash ( P < .001; n = 4 animals).

    Journal: Endocrinology

    Article Title: Robust serotonin activation of the kisspeptin GnRH pulse generator in male and female mice

    doi: 10.1210/endocr/bqag034

    Figure Lengend Snippet: Effects of serotonin and 5-HT receptor compounds on ARN KISS neuron firing in acute brain slices from diestrous female mice. (A) Robust excitatory effect of 90 seconds puff of 40 µM serotonin on firing rate of a middle ARN kisspeptin neuron. (B) Inhibitory effect of 90 seconds puff of 60 µM serotonin on firing rate of a caudal ARN kisspeptin neuron initially stimulated to fire by a 200 nM puff of NKB. (C) Rostral ARN kisspeptin neuron not responding to 60 µM puffs of serotonin but later activated by NKB. (D) Summary of percentage of rostral (rARN), middle (mARN), and caudal (cARN) kisspeptin neurons excited or inhibited by serotonin. (E) Caudal ARN kisspeptin neuron activated by serotonin (40 µM) in the absence and presence of methiothepin (100 µM). (F) Middle ARN kisspeptin neuron in which the excitatory effect of serotonin (40 µM) is blocked by methiothepin (100 µM). (G) Middle ARN kisspeptin neuron activated by serotonin (40 µM) in the absence and presence of SB228357 (100 µM). (H) Caudal ARN kisspeptin neuron in which zacopride (2 µM) facilitates serotonin excitation. (I) Whole-cell recording from an ARN KISS neuron in the continuous presence of TTX, CNQX, DAP5, and bicuculline, showing depolarization during bath application of 5-HT (30 µM). (J) Summary of mean membrane potential measured predrug, during 5-HT application, and following wash ( P < .001; n = 4 animals).

    Article Snippet: Stock solutions of GABAzine (SR95531, 5 mM, Tocris, UK), CNQX (10 mM, Tocris, UK), and DAP5, (50 mM, Tocris, UK) were prepared with Milli-Q water or NaOH for DAP5.

    Techniques: Membrane